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KMID : 0383820150780010027
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Tuberculosis and Respiratory Diseases
2015 Volume.78 No. 1 p.27 ~ p.30
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A Case of the Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) Following Isoniazid Treatment
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Lee Jin-Yong
Seol Yun-Jae
Shin Dong-Woo
Kim Dae-Young
Chun Hong-Woo
Kim Bo-Young
Jeong Shin-Ok
Lim Sang-Hyok
Jang An-Soo
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Abstract
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The drug reaction with eosinophilia and systemic symptom (DRESS) syndrome is a severe adverse drug-induced reaction which includes a severe skin eruption, fever, hematologic abnormalities (eosinophilia or atypical lymphocytes) and internal organ involvement. The most frequently reported drug was anticonvulsants. The diagnosis of DRESS syndrome is challenging because the pattern of cutaneous eruption and the types of organs involved are various. The treatments for DRESS syndrome are culprit drug withdrawal and corticosteroids. Here we report a 71-year-old man with skin eruption with eosinophilia and hepatic and renal involvement that appeared 4 weeks after he had taken anti-tuberculosis drugs (isoniazid, ethambutol, rifampicin, and pyrazinamide), and resolved after stopping anti-tuberculosis drugs and the administration of systemic corticosteroids. DRESS recurred after re-challenging isoniazid, we identified isoniazid was causative drug.
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KEYWORD
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DRESS Syndrome, Tuberculosis, Isoniazidcytes
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